| Country | City | Status | Chapter |
| Austria | Organizing | Austrian Transhumanist Association | |
| Belgium | Brussells | Organizing | HEALES : the Healthy Life Extension Society |
| Belgium | Brussels | Organizing | Brussels Transhumanist Association |
| Canada | Toronto | Chapter | Toronto Transhumanist Association |
| China | Chapter | Chinese Transhumanist Network | |
| Croatia | Organizing | Croatian Transhumanist Association | |
| Czech Republic | Praha | Chapter | Ceska Asociace Transhumanistu |
| Finland | Helsinki | Chapter | Suomen Transhumanistiliitto |
| France | Paris | Chapter | Technoprog! (French Technoprogressive Assoc) |
| Germany | Munich | Chapter | DeTrans - Deutsche Gesellschaft für Transhumanismus |
| Israel | Chapter | Transhumanistim Israelim and Singulariut |
|
| Israel | Organizing | Haarachat Haim | |
| Italy | Milan | Chapter | Associazione Italiana Transumanisti |
| Italy | Rome | Chapter | Network dei Transumanisti Italiani |
| Japan | Tokyo/Chiba | Organizing | Japanese Transhumanist Association |
| Kosovo | Prishtina | Organizing | Transhumanizmi |
| Latin America | Organizing | Asociación Transhumanista | |
| Norway | Oslo | Chapter | Norsk Transhumanistforbund |
| Portugal | Chapter | Humanity+ Portugal | |
| Russia | Moscow | Chapter | Russian Transhumanist Movement |
| Second Life | Extropia Core | Chapter | SL-Transhumanists |
| Slovenia | Ljubljana | Chapter | Slovenian Transhumanist Association |
| South Africa | Organizing | South African Transhumanists | |
| Sweden | Organizing | Svenska Transhumanister | |
| UK | London | Chapter | UK Transhumanist Association |
| Ukraine | Lviv | Organizing | Ukrainian Transhumanist Organization |
| USA | Austin TX | Organizing | Austin Intelligentsia |
| USA | Chicago IL | Chapter | Chicago Transhumanist Association |
| USA | Florida | Chapter | Florida Transhumanists |
| USA | Hartford CT | Organizing | H+ Hartford |
| USA | Honolulu HI | Chapter | Hawaiian Transhumanist Group |
| USA | Ithaca NY | Chapter | Cornell Transhumanist Society |
| USA | Las Vegas NV | Organizing | HumanityPlus Las Vegas |
| USA | Los Angeles CA | Organizing | Los Angeles Transhumanists |
| USA | New York City NY | Chapter | New York Transhumanist Association |
| USA | Phoenix AZ | Organizing | H+ Phoenix |
| USA | San Diego CA | Organizing | Humanity+ San Diego |
| USA | San Jose CA | Organizing | Silicon Valley Transhumanist Assoc. Meetup |
| USA | Seattle WA | Chapter | Seattle Transhumanist Discussion Group |
| USA | Stanford CA | Chapter | Stanford Transhumanist Association |
| USA | Staten Island NY | Chapter | New York Transhumanist Association |
| USA | Tampa FL | Chapter | Florida Transhumanist Association |
| USA | Tempe AZ | Organizing | Life Extension Club |
| USA | Tucson AZ | Organizing | H+ Tucson |
| USA | Twin Cities MN | Organizing | H+ Campus Transhumanists |
| USA | Washington DC | Chapter | Washington DC Transhumanists |
Local chapters of Humanity+ are autonomous, and members of H+ chapters do not have to join Humanity+. However recognized chapters may collect dues for membership, and may purchase voting (supporting) memberships in Humanity+ for their local members who desire them at half the usual amount. To be recognized as an H+ chapter groups must appoint a liaison(s) to Humanity+ and submit a charter defining the goals of the group and the geographic area to be served (if any; chapters may also serve occupational or interest groups). Local groups seeking recognition as chapters must have at least three basic members, and one voting (supporting or sustaining) member. Members of Humanity+ are not automatically members of any local chapters of Humanity+ however; local chapters may have additional membership dues and requirements. Liaisons should subscribe to the general discussion list and any local Humanity+ list for their area.